SERPINF1 and cancer: In addition to the potent and selective anti-angiogenic function, PEDF has neuroprotective, antioxidant, anti-inflammation, and antithrombotic properties, and has been associated with therapy of atherosclerotic diseases, choroidal neovascularization, cancer, etc. (Takenaka et al., 2008; Rychli et al., 2009; Yamagishi and Matsui, 2010, 2014; Wen et al., 2017).