CRH and Anxiety: The corticotropin-releasing hormone/corticotropin-releasing factor (CRH/CRF) family of ligands and receptors are important mediators of the neuroendocrine and behavioral response to stress, and hyperfunction of CRH and its type 1 high-affinity receptor (CRHR1) have been implicated in the pathology of chronic stress, including the development of anxiety and mood disorders (Muller and Wurst, 2004; Aubry, 2013).