CRHR1 and anxiety disorder: CRHR1 antagonists have been suggested as a potential treatment for addiction in humans, especially alcohol use disorders (Zorrilla et al., 2013), due to the comorbidity between alcohol use disorders and anxiety disorders (Grant et al., 2004; Bruijnzeel and Gold, 2005) and polymorphisms in the Crhr1 gene related to alcohol use disorders in humans (Treutlein et al., 2006; Chen et al., 2010) and changes in Crhr1 expression related to alcohol drinking phenotypes in rodents (Hansson et al., 2006a, 2007; Molander et al., 2012).