In contrast, recombinant IL-33 (rIL-33) facilitated IFN-γ-producing γδ T and NK cells and inhibited IL-17+ γδ T cells, revealing a role of IL-33 in regulating innate IFN-γ production and antiviral responses in LCMV-infected hepatitis [49, 50]. The gene discussed is IL33; the disease is hepatitis A virus infection.