CD8A and hepatocellular carcinoma: There are also research teams studying the role of IL-33 in other liver diseases; for example, oncogenesis and progression of hepatocellular carcinoma (HCC) are associated with aberrant IL-33 expression [67], and upregulation of IL-33, primarily produced by CD8+ CD62L− KLRG1+ CD107a+ T cells, may indicate prolonged patient survival [68].