Although we could observe a correlation between S100A8/A9 and IL-8 levels in the serum and saliva as well, neither IL-8 nor any other cytokine or chemokine we determined in the serum and saliva provides the potential to differentiate between acute tonsillitis, peritonsillitis, and peritonsillar abscess. Here, CXCL8 is linked to Recurrent tonsillitis.