Additionally, as mentioned above, increased levels of S100A8/A9 could be observed in serum of patients with varied diseases concerning the bowel, the joints, the heart, the skin, and multiple other organs, and enhanced S100A8/A9 levels have been observed in crevicular fluid of patients suffering from periodontitis [26, 27, 34, 48, 49]. The gene discussed is S100A8; the disease is periodontitis.