For example, MYO1F present in the first cluster network (Fig. 3A) has an ability to guide immune cell motility15; OAZ1 could regulate intracellular polyamine levels16; MBD3 is an essential requirement for pluripotency of embryonic stem cells17; DOT1L is over-expression in ovarian cancer, driving cell cycle progression18. Here, MBD3 is linked to ovarian carcinoma.