LDLR and coronary artery disorder: We also performed conditional analysis with a commonly replicated variant in the LDLR gene that is associated with decreased LDL-C levels and lower risk for coronary heart disease (CHD)5,6,39 (rs6511720; pgwas = 0.009 in the Hutterites) and confirmed that the identified rare variants in the Hutterites have independent and opposite effects compared to the common GWAS variant at this locus (Table 3).