The effects of baicalin on rodent colitis are better addressed to act via abrogation of oxidant stress8, T-helper 17 (Th17)/regulator T cell (Treg) balance9, toll-like recptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling10, and macrophage inhibitor factor (MIF) signaling11. The gene discussed is TLR4; the disease is colitis.