NOTCH1 and neoplasm: To investigate whether LINC00152 exerts tumor-promoting functions in CRC by modulating the miR-139-5p/NOTCH1 axis, we first checked the effects of miR-139-5p and NOTCH1 on LINC00152-induced cell proliferation, and observed that miR-139-5p overexpression or NOTCH1 knockdown blocked the LINC00152-induced CRC cell growth (Fig. 6a).