PRKN and breast cancer: Compared with normal breast tissues and normal breast MCF10A cells, Parkin expression was decreased in various breast cancer cells, including MCF7 (ER + /PR + /HER2−), MDA-MB231 (ER−/PR−/HER2−), T47D (ER + /PR + /HER2−), SK-BR3 (ER−/PR−/HER2+), and ZR-75-1 (ER + /PR + /HER2+) (Supplementary Fig. 1b).