Finally, we validated the TP53-uc.339-miR-339/-663b/-95-CCNE2 axis in 22 primary NSCLC samples, where we observed that when TP53 was downregulated and uc.339 was upregulated (Fig. 9b), miR-339, -663b, and -95 were downregulated (Fig. 10c) and CCNE2 protein expression was increased (Fig. 10d). The gene discussed is TP53; the disease is non-small cell lung carcinoma.