TP53 and non-small cell lung carcinoma: By analyzing the endogenous expression of uc.339 in the three NSCLC cell lines and one CRC line (Supplementary Fig. 1a), we noticed that while uc.339 is expressed at the lowest levels in wild-type (wt) TP53-expressing cells (A549), the expression was the highest in TP53-null H1299 cells (Supplementary Fig. 1a; Supplementary Fig. 10).