Because of published reports that NOS3 rs1799983 (+894 G>T, OMIM +163729), rs2070744 (‐786 T>C), and rs1800779 (‐922 A>G) were associated with hypertension and the BP response to antihypertensive pharmacotherapy and/or exercise training, over a decade ago, we began several discovery phase candidate gene association studies for their associations with PEH (Augeri et al. Here, NOS3 is linked to Hypertension.