NOS3 and hypertensive disorder: For, VIGOROUS may override the more vasoconstrictive nature of the vasculature of AF at rest in people who are in the early stages of hypertension such as our sample was, by increasing shear stress, NOS3 expression, and NO production and availability, while simultaneously decreasing the production and availability of endothelin‐1‐21 and other vasoconstrictors; thereby, leading to immediate, clinically meaningful reductions in BP that persist for the remainder of the day (Augeri et al.