The possible DC suppressive effect of IL-10 and TGF-β in a chronic HPV-infected local microenvironment is evidenced by a correlation between elevated levels of TGF-β and IL-10 positive Treg cells, regulatory DCs and impaired CTL responses in cervical cancer epithelium compared to normal cervix [95]. The gene discussed is TGFB1; the disease is cervical carcinoma.