A recent analysis that evaluated the causes of amenorrhea among OF patients at the time of repair using FSH, estradiol, and AMH testing and pelvic ultrasound found that 42% were unexplained, 27% were likely from breastfeeding, 12% were from polycystic ovarian syndrome (PCOS), 9% were from use of the depot medroxyprogesterone acetate injectable, 6% were from hypergonadotropic hypogonadism, and 3% were from hypogonadotropic hypogonadism [10]. This evidence concerns the gene BRD2 and hypogonadotropic hypogonadism.