The C allele of rs16944 and rs1800587, and the T allele of rs1143634 has been speculated to influence the risk of POAG by altering the expression level of the respective proteins, because the sites of rs1800587 and rs16944 are located within the transcriptional promoter regions of the IL-1α and IL-1β genes, respectively, and the site of rs1143634 is within the coding region of the IL-1β gene [24, 25]. The gene discussed is IL1A; the disease is open-angle glaucoma.