CPZ and cancer: Indeed, CPZ acts as: a) a potent and specific inhibitor of the mitotic kinesin KSP/Eg5, thus hindering cancer cell proliferation via mitotic arrest and accumulation of defective, monopolar spindles [101] and b) an inhibitor of the AKT/mTOR signal transduction axis in human glioma cells, thus eliciting autophagic cell death [102].