For example, ALK inhibitors crizotinib or ceritinib and other second-generation inhibitors are dramatically effective in all tumors displaying dependence on an over-activated ALK kinase, usually due to the EML4-ALK rearrangement, such as anaplastic large cell lymphoma, neuroblastoma and non-small-cell lung carcinoma [40]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.