For example, Cruz-Bermúdez et al. showed that cybrids containing mutations in ND1 (m.3460G > A), ND4 (m.11778G > A) and ND6 (m.14484 T > C) of mtDNA exhibit the enhanced tumorigenicity [5]; Ishikawa et al. revealed that the G13997A and 13885insC mutations in the coding region of ND6 gene confer an increased metastatic potential in mouse P29 cell line that originated from Lewis lung carcinoma [6]. Here, MT-ND6 is linked to Carcinoma, Lewis Lung.