In conclusion this study, showing the activation of a cross-talk between p53 and STAT3 by apigenin, unveils new molecular mechanisms through which this flavonoid leads to apoptosis and autophagy induction in PEL, an aggressive lymphoma harboring wt p53 and constitutive STAT3 activation, that is very difficult to successfully treat. The gene discussed is STAT3; the disease is primary effusion lymphoma.