Ectopic synaptogenesis was previously described in several retinal degeneration models, however, involving various connections: between cones and PKC-IR BCs in the OPL of rd1 and Rho−/− mice (both of which have rod-specific dysfunction); between rods and cone-BCs in CNGA3−/− mice (with cone-specific dysfunction); and between cones and horizontal cells in the ONL of Δ14-17 Cacna1f-KO mice [20,45,52,53]. This evidence concerns the gene PDE6B and retinal degeneration.