Serum hormone test was noteworthy for hypothyroidism (Free triiodothyronine (FT3, 1.73 pg/ml), free thyroxine (FT4, 0.78 ng/dl), thyroid stimulating hormone (TSH, 8.3 mIU/L) with negative antibody (thyroglobulin antibody, thyroid peroxidase antibody and thyrotrophin receptor antibody), elevated adrenocorticotropic hormone (ACTH, 150.00 pg/ml) and decreased 24-hours urine free cortisol (81.2 nmol/24h). This evidence concerns the gene POMC and hypothyroidism.