Consequently, ERK 1/2 activation results in an overexpression of the genes coding for several mediators of the mesangial cells proliferation and sclerosis, such as the transforming growth factor-β1 (TGF- β1), the plasminogen activator inhibitor-1 (PAI-1), fibronectin and collagen, which lead to the progression of renal damage and cardiovascular disorders along with Ang II generation, which is called “RAAS escape’”. This evidence concerns the gene SERPINE1 and cardiovascular disorder.