Aliskiren has been shown to be effective in lowering BP and affect proteinuria, left ventricular mass index and brain natriuretic peptide (BNP) levels in patients with albuminuria, LVH and HF when in combination with ACEs/ARBs, [15, 20, 28, 29] and these factors are also associated with the increased risk of cardiovascular diseases. This evidence concerns the gene NPPB and hydrops fetalis.