We have discovered interesting viewpoints, based on these investigations a) the functional mechanisms of silibinin in AML cells, whether it is through Nrf2/ARE/VDR, Nrf2/ARE/RXRα, jun families or C/EBP families is to eventually regulate cell differentiation to exert an anti-cancer effect [21] [17]. The gene discussed is RXRA; the disease is acute myeloid leukemia.