Seribantumab (MM-121 or SAR256212) is a fully human monoclonal antibody targeting HER3.[109] In preclinical models of lung cancer and HNSCC, seribantumab decreased HER3 phosphorylation.[109, 110] A preclinical animal model of ovarian cancer treated with seribantumab also showed decreased tumor growth.[111]. This evidence concerns the gene ERBB3 and ovarian cancer.