EGFR and non-small cell lung carcinoma: The patients were treated with patritumab 9 mg/kg and 18 mg/kg every 3 weeks in combination with erlotinib with no grade 3 toxicities.[105] The phase II HERALD trial randomized patients with platinum-resistant, EGFR wild-type, advanced or metastatic NSCLC to erlotinib with high dose patritumab, low dose patritumab or placebo.