BRAF and malignant colon neoplasm: EV20 is an humanized anti-HER3 antibody, which interferes with ligand-dependent and independent signaling and causes internalization of HER3 in several cancer cell lines.[143] EV20 reversed resistance to vemurafenib in BRAF-V600E mutant colon cancer stem cells.[35] HuHER3-8 is an anti-HER3 antibody that, when combined with BRAF inhibitors, reduces tumor growth in melanoma xenografts with WT BRAF [144] or V600E mutated BRAF.