For example, ADAM17, a disintegrin and metalloproteinase 17, mediates motility and angiogenesis associated with colon cancer cells through neuregulin-1.[26] Any process modulating the expression of HER2, HER3, and HER4 on the cell surface alter the effect of HRG/HER signaling. The gene discussed is ERBB2; the disease is malignant colon neoplasm.