According to the hepatic lesion alterations embodied in serum hepatic enzymes at different reperfusion time (Supplementary Figure 1B, 1C), we chose the hepatic repair phase (reperfusion time point: 12h) for further studies to elucidate the role of PARP-1 up-regulation during warm IR in tumor recurrence. The gene discussed is PARP1; the disease is neoplasm.