ESCC patients with and without FGFR1 amplification were comparable in the demographic and baseline variables except that the percentage of heavy drinkers was significantly higher in patients with FGFR1 amplification than those without FGFR1 amplification (86.6% vs 43.1%, P<0.001) (Table 1). Here, FGFR1 is linked to esophageal squamous cell carcinoma.