Loga et al. investigated the prevalence of FGFR1 amplification in a tissue microarray containing 346 esophageal adenocarcinomas and 254 ESCCs using dual-labeling fluorescent in situ hybridization (FISH) analysis and found that FGFR1 amplification correlated with the histologic subtype of ESCC (9.4% vs. esophageal adenocarcinoma 1.6%, P<0.001) [13]. Here, FGFR1 is linked to esophageal adenocarcinoma.