The frequency of FGFR1 amplification, as detected by FISH analysis in our cohort, was 12.1%, which was higher than 9.4% reported by Loga et al. for a Caucasian ESCC patients cohort, [13] but lower than 21.4% for a small Korean cohort reported by Kwon et al [14]. Here, FGFR1 is linked to esophageal squamous cell carcinoma.