Furthermore, ESCC patients with FGFR1 amplification had significantly higher IHC scores (mean 121.8 ± 36.8; range, 78 to 242) than those without FGFR1 amplification (mean 22.1 ± 19.9; range, 0 to 75) (P<0.001) (Figure 3) and all patients with FGFR1 amplification fell into the high FGFR1 expression group. Here, FGFR1 is linked to esophageal squamous cell carcinoma.