Future experiments will measure other immune cells including myeloid-derived suppressor cells, NK cells, M1 and M2 macrophages as well as time-course studies of the actual numbers of CD4+ helper lymphocytes, FoxP3+Treg, and CD8+ cytotoxic T lymphocytes during pancreatic tumor growth and metastasis in control and splenectomized mice. This evidence concerns the gene CD4 and pancreatic neoplasm.