ALB and hematocrit: To further investigate intratumoral vascularity and 64Cu-ATSM uptake regions, in vivo high-resolution dual-isotope simultaneous SPECT/PET/CT imaging [29] with a blood pool-detecting SPECT agent,99mTc-labeled human serum albumin (99mTc-HSA) and a hypoxia-detecting PET agent,64Cu-ATSM, was conducted with bevacizumab-treated HT-29 tumors and the bevacizumab-untreated control.