In this study, we demonstrated that inhibition of HDAC6 with TA (a highly selective inhibitor of HDAC6) or silencing with siRNA inhibits EMT in cultured human peritoneal mesothelial cells and attenuates activation of fibroblasts, deposition of ECM, induction of inflammatory responses, and angiogenesis in a mouse model of peritoneal fibrosis induced by chronic exposure to high glucose dialysate. This evidence concerns the gene HDAC6 and Peritoneal Fibrosis.