CASP3 and cancer: The changes to the morphology of the remaining adherent MCF-7 and NCI-H460 observed under fluorescence microscopy were characteristic of necrosis and the complete absence of changes in caspase-3 activity over the time frame of the experiments strengthens the argument for necrosis being the predominant cell death modality leading to the recorded reduction in viable cancer cell mass in the presence of OGT 2115.