Mechanistically, the over-expression of the miR-106b∼25 cluster during NASH-associated liver carcinogenesis may be attributed to a markedly increased level of yes-associated protein 1 (YAP1) and TEA domain transcription factor 4 (TEAD4) proteins (Figure 4G), members of YAP and TAZ transcriptional effectors of the Mcm7 gene [16]. This evidence concerns the gene YAP1 and metabolic dysfunction-associated steatohepatitis.