Moreover, the level of CTNNB1, mTOR, and AREG was also increased by 3-, 6-, and 1.4-times in NASH/fibrotic liver tissue, suggesting activation of the Wnt/β-catenin, mTOR, and EGF signaling pathways at the preneoplastic stage of hepatocarcinogenesis. This evidence concerns the gene CTNNB1 and metabolic dysfunction-associated steatohepatitis.