Moreover, the level of CTNNB1, mTOR, and AREG was also increased by 3-, 6-, and 1.4-times in NASH/fibrotic liver tissue, suggesting activation of the Wnt/β-catenin, mTOR, and EGF signaling pathways at the preneoplastic stage of hepatocarcinogenesis. Here, AREG is linked to metabolic dysfunction-associated steatohepatitis.