In particular, TCF7L2 was shown to promote breast cancer cell invasion by upregulation of miR-21 [38] and Wnt ligand induced β-catenin activation is also known to enhance invasion and metastasis of TNBC cells [22, 39], suggesting the regulation of invasion could be mediated by modulating Wnt pathway in TNBC. Here, TCF7L2 is linked to breast cancer.