Our data show that SID peptide downregulates Wnt/β-catenin reporter activity and direct Wnt target genes (LEF1, TCF7L2, CD44, PLAU, MT1-MMP, MMP9, HMGA2) involved in breast cancer invasion and metastasis (Figure 3A-3E, Table 2, 3). The gene discussed is LEF1; the disease is breast cancer.