Compared to the WT controls, the EV group had no effect on response to cisplatin, however, both of the mutated ADAMTS16 (S787Y and S1170L) cell lines had a significantly better response to cisplatin (p<0.05 and p<0.01, respectively), as indicated by a reduction in tumor weight or the number of tumor nodules (Figure 6B). This evidence concerns the gene ADAMTS16 and neoplasm.