SDC1 and nervous system disorder: When analyzing human central nervous system (CNS) tissue from patients with multiple sclerosis (n = 7) and other neurological diseases (OND, n = 5) (Tables 1 and 2), plasma cells (CD138+) were found at various locations, including parenchymal, perivascular and meningeal areas (Fig. 1a, Additional file 1 Fig. S1).