Overall cancer risk was significantly elevated in anti-TIF1-γ-positive patients (SIR = 17.28, 95% CI 11.94 to 24.14), anti-NXP2-positive patients (SIR = 8.14, 95% CI 1.63 to 23.86), anti-SAE1-positive patients (SIR = 12.92, 95% CI 3.23 to 32.94), and in MSAs- patients (SIR = 3.99, 95% CI 1.96 to 7.14). Here, MORC3 is linked to cancer.