HMGCR and cancer: Besides anti-TIF1-γ antibodies, a few studies have indicated that the presence of other MSAs, including anti-nuclear matrix protein (NXP2), anti-Jo-1, anti-Mi-2β, anti-HMGCR, is correlated with cancer in IIMs as well [3–12], but these findings have not been consistently replicated in other studies [13–16].