A significant effect was found in one study for selenium against placebo in 53 women for fasting glucose (MD 4.66 mg/dl, 95%CI 3.23 to 6.09, p < 0.00001), insulin resistance (HOMA-IR) (MD 0.24 95%CI 0.06 to 0.42, p = 0.008), total testosterone (MD 0.18 ng/ml, 95%CI 0.09 to 0.27, p < 0.0001), SHBG (MD 12.80 nmol/l, 95% CI 6.22 to 19.38, p < 0.0001) and FAI (MD 3.93, 95% CI 3.54 to 4.32, p < 0.00001) [40]. Here, SHBG is linked to Insulin resistance.