Significant benefits were found for fasting glucose (four trials, 132 participants, MD-1.17, 95% CI -1.72 to −0.63, p < 0.01), [34, 36, 41, 45]; fasting insulin (four trials, 132 participants, MD −2.7 μU/ml, 95% CI -3.9 to −1.5, p < 0.01) [34, 36, 41, 45] and reduced insulin resistance (HOMA-IR) (two trials, 76 participants, MD -1.3, 95% CI -1.6 to −1.0, p < 0.01) [31, 36] (Table 2). The gene discussed is INS; the disease is Insulin resistance.