A significant treatment effect was found for the combination group for reduced days to ovulation (MD −3 days, 95% CI -3.51 to −2.49, p < 0.01), pregnancy rates (RR 1.98, 95% CI 1.19 to 3.31, p < 0.01), FSHmIU/l (MD 0.40, 95% CI 0.22 to 0.58, p < 0.01), LH mIU/l (MD -2.3, 95% CI -2.55 to −2.05, p < 0.01), and reduced miscarriage (RR 0.62, 95% CI 0.22 to 1.74, p = 0.36). The gene discussed is PLOD1; the disease is spontaneous abortion.