Further differences could be seen when comparing the results of preliminary simulations of fumarase deficiency (Fig. 2) that showed MitoCore replicating the efflux of fumarate seen in patients while also using plausible compensatory mechanisms, which would provide a promising starting point for further simulations and analysis (such as determining the effect of varying parameters). This evidence concerns the gene FH and hyperinsulinemic hypoglycemia, familial, 4.