Chickens lack RIG-I (retinoic acid-inducible gene I), but the function of sensing viral infections can be performed by LGP2 and MDA5, which can interact with MAVS (mitochondrial antiviral signaling protein) or STING (stimulator of IFN genes) to stimulate the expression of IFNs [52–54]. This evidence concerns the gene DHX58 and viral infectious disease.