CASQ2 and catecholaminergic polymorphic ventricular tachycardia: 2010). Disrupted CASQ2 polymerization dynamics may impair Ca2+ handling during increased physiological demands which could explain the CPVT phenotype (Bal et al. 2010). This has been further supported by the study of a novel dominant CASQ2 mutation. Predictive modeling of this mutation has suggested it might disrupt CASQ2 assembly (Gray et al. 2016).