2008; Touitou et al. 2014). Although FMF mutations have been reported in every exon, the mutations in exon 10 of the MEFV gene are mostly responsible for causing FMF symptoms (Booth et al. 1998; Aksentijevich et al. 1999). Weinert's group identified a group of 28 disease‐causing mutations (DCMs) and their impact on the protein structure of pyrin (Weinert et al. 2009). Here, MEFV is linked to familial Mediterranean fever.