Several single nucleotide polymorphisms conferring susceptibility to type 1 neovascularization (including an ARMS2 allele, rs10490924) have indeed been shown to be shared between cohorts of patients with neovascular AMD and neovascular central serous chorioretinopathy, where each cohort was phenotyped diligently.38 This study also found a few patients with polypoidal lesions in a neovascular central serous chorioretinopathy cohort, but none in the neovascular AMD cohort. Here, ARMS2 is linked to central serous retinopathy.