Studies by many consortia and other groups found that a subset of G3 and G4 MBs, but not SHH and WNT tumors, are characterized by high levels of EZH2 expression and H3K27me3 marks but impaired H3K4 methylation, a combination of histone marks consistent with a stem/progenitor cell-like identity that typifies G3 MBs (Fig. 5) [14]. Here, SHH is linked to Mobius syndrome.