Of the three false positive DNM (11.7%; Supplementary Material, Table S1) one, within LAMC2, is likely a result of germline mosaicism because, although not observed in either parent, it is observed in an unaffected sibling in addition to the SLE proband (13), and the other two variants are within KRTAP10–2 and KLRC1—both members of highly homologous gene families. The gene discussed is KLRC1; the disease is systemic lupus erythematosus.