CFTR and cystic fibrosis: Indeed, several studies, including from our group, showed that exposure to P. aeruginosa strains or exoproducts reduced the expression of wt-CFTR at the apical membrane and CFTR-mediated Cl− secretion through non-CF human AEC (Swiatecka-Urban et al., 2006; Rubino et al., 2014; Trinh et al., 2015).