In this study, we investigated the association between methylation of multiple CpG sites across the regulatory regions of AXL at birth and risk of childhood asthma symptoms, taking into consideration the underlying genetic variation in AXL. We first assessed the association in a subset of 246 subjects from the Children’s Health Study (CHS), then sought to replicate the associations in a separate population of 1038 CHS subjects. Here, AXL is linked to asthma.