SOCS3 and tuberculosis: Our results are in line with previous studies addressing the impact of a macrophage-specific SOCS3 deficiency on the outcome of experimental toxoplasmosis (16) and TB (15) which implicated the reduced IL-12/IL-23 production and subsequent impaired Th1 immune response to be involved in the impaired control of Mtb infection in LysMcreSOCS3loxP/loxP mice.