Via activating CB1, CB2, or other cellular targets, both endo- and pCBs were already convincingly shown to exert complex [e.g., antiproliferative and proapoptotic effects, inhibition of angiogenesis, inhibition of tumor cell chemotaxis via activating CB2/CXCR4 heteromers, etc. (27, 125–134)] antitumor effects in most of the test systems in vitro. This evidence concerns the gene CNR2 and neoplasm.