The E6 proteins of HPV8 and other β-HPV-types are able to inhibit apoptosis (Jackson and Storey, 2000; Jackson et al., 2000; Struijk et al., 2008) and interfere with the repair of UVB-induced DNA damage and repair (Wallace et al., 2012; Hufbauer et al., 2015) and thus favor the accumulation of mutations including UV-induced inactivating mutations of p53, which are thought to be a crucial step in the development of AKs and cSCC also in humans (Brash et al., 1991; Kemp et al., 1993; Jiang et al., 1999). The gene discussed is TP53; the disease is skin squamous cell carcinoma.