The effects of the TRIB1/p53 axis on HCC were further examined by assessing the expression of β-catenin and its target genes c-myc and matrix metalloprotease-7 (MMP-7) in HepG2 and Huh7 cells in response to TRIB1 silencing or overexpression. This evidence concerns the gene TRIB1 and hepatocellular carcinoma.