To examine the correlation between TRIB1 and p53 in HCC, HepG2 and Huh7 cells were transfected with siRNA against TRIB1 or control siRNA or a plasmid overexpressing TRIB1, and the expression of TRIB1 and p53 was measured by qRT-PCR, western blotting and immunocytochemistry. Here, TRIB1 is linked to hepatocellular carcinoma.