GRIN1 and Alzheimer disease: Despite neuronal death, AD is characterized by an increase in Aβ peptide, which could be toxic through its interaction (probably in oligomeric form) with a NMDA receptor subunit, GluN1 (Amar et al., 2017) present at the dendritic spines but also when it interacts with the glutamate receptor subunits present at extrasynaptic sites.