The majority of BRAF mutations in melanoma occur at V600: 66–94% of mutations occur in codon 600 and involve a valine-to-glutamine substitution (V600E) [6, 10, 11]; 6–28.6% of mutations involve lysine substitutions (V600K) [10, 11]; and 2.3–14.7% of mutations involve aspartic acid or arginine substitutions (V600D or V600R, respectively) [10]. This evidence concerns the gene BRAF and melanoma.