By multivariate analyses, independent predictors of early recurrence in the overall cohort were BMI >27.5 kg/m2 (HR = 2.185, p = 0.010), BCLC stage B-C (HR = 2.526, p = 0.001), serum AFP level >20 ng/mL (HR = 2.212, p = 0.006) and histological cirrhosis (HR = 2.989, p<0.001) (S1 Table). This evidence concerns the gene AFP and Cirrhosis.